Senior management

Paradigm’s strategic management is driven by a team with significant experience in drug development and the execution of clinical studies.

Our Non-Executive Chairman, Mr Graeme Kaufman, has broad experience in the development and commercialisation of pharmaceutical drugs (prior executive roles including CFO at CSL Limited, executive VP of Mesoblast Ltd).


Our Chief Executive Officer, Mr Paul Rennie, has been involved in drug development and a number of pre-clinical and clinical trial programs (was the inaugural COO of Mesoblast and most recently as Executive VP, New Product Development at Mesoblast Ltd). Mr. Rennie has extensive experience in commercialising Intellectual Property.

Our Chief Scientific Officer, Dr Ravi Krishnan, is a basic scientist with a long-standing interest and experience in experimental pathology, transplantation immunology, gene and stem cell therapy. He has also had significant experience in investigating novel compounds with immune modulatory effects, anti-inflammatory and anti-angiogenic properties.

Our Global Head of Clinical Development, Sharon Charles, has over 30 years’ experience in the healthcare sector across geographies, with 24 years in clinical and commercial development. She has a strong track record in developing world-class products and services and growing regional business. Sharon has worked at world leading biotech companies, including Amgen and CSL, and brings a depth of biotech development understanding and skill.

Our CFO and Company Secretary, Mr Kevin Hollingsworth, has previous experience with publicly listed biopharmaceutical start-ups such as Mesoblast Ltd and Patrys Ltd.


Our Chief Operations Officer, Dr Claire Kaufman, is an experienced Veterinary Surgeon. After 8 years of clinical veterinary and organisational experience in private practice and animal welfare organisations, Claire pursued work in pre-clinical Immunology research and was responsible for co-ordinating preclinical therapeutic trials. Claire also has extensive experience with the use of Pentosan Polysulphate Sodium (PPS) in clinical veterinary practice.

Our Clinical Operations Manager, Melanie Duiker, joined the Paradigm team in 2017. With 25 years of experience in clinical research, she is responsible to lead, co-ordinate and oversee our clinical research activities within Australia and abroad. Her industry experience includes managing clinical operations at local, as well as international level, with 8 years managing clinical operations with Europe.  She brings broad experience in clinical study development and operations, including: Feasibility, Forecasting and budget management, Quality Management, Audit Management and Vendor Management.