PEER-REVIEWED PUBLICATIONS

A double-blind placebo-controlled phase 2 study to evaluate the safety and tolerability of pentosan polysulfate sodium in subjects with mucopolysaccharidosis type VI (MPS VI)

Authors: Roberto Giugliani1, Paula Frassinetti Vasconcelos de Medeiros2, Michael Imperiale3, Ravi Krishnan3, Michael Eldon4, Sharon Charles3

An open-label single-centre pilot study to evaluate the safety and tolerability of pentosan polysulfate sodium in subjects with mucopolysaccharidosis type I (MPS I).

Authors: Drago Bratkovic1, Sharon Charles2, David Ketteridge1, Ravi Krishnan2, Michael Imperiale2 Affiliations: 1Women’s and Children’s Hospital, South Australia; 2Paradigm Biopharmaceuticals Ltd., Melbourne, Australia

Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulfate Sodium (PPS) and implications for pain associated with knee osteoarthritis.

Source: Stapledon CJM, Tsangari H, Solomon LB, Campbell DG, Hurtado P, Krishnan R, et al. (2019) Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulfate Sodium (PPS) and implications for pain associated with knee osteoarthritis. PLoS ONE 14(9): e0222602. https://doi.org/10.1371/journal.pone.0222602

Improved clinical outcome measures of knee pain and function with concurrent resolution of subchondral Bone Marrow Edema Lesion and joint effusion in an osteoarthritic patient following Pentosan Polysulfate Sodium treatment: a case report.

Source: Sampson, M., Kabbani, M., Krishnan, R., Nganga, M., Theodoulou, A., & Krishnan, J., 2017. Improved clinical outcome measures of knee pain and function with concurrent resolution of subchondral Bone Marrow Edema Lesion and joint effusion in an osteoarthritic patient following Pentosan Polysulfate Sodium treatment: a case report. BMC Musculoskeletal Disorders, 18, pp. 396-340. DOI 10.1186/s12891-017-1754-3

Pentosan Polysulfate: a Novel Glycosaminoglycan-Like Molecule for Effective Treatment of Alphavirus-Induced Cartilage Destruction and Inflammatory Disease.

Source: Herrero, L.J., Foo, S.S., Sheng, K.C., Chen, W., Forwood, M.R., Bucala, R. and Mahalingam, S., 2015. Pentosan polysulfate: A novel glycosaminoglycan-like molecule for effective treatment of alphavirus-induced cartilage destruction and inflammatory disease. Journal of virology, 89(15), pp.8063-8076.

Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function I n V i v o in Rats Subjected to Pressure Overload by Aortic Banding

Source: Vistnes, M., Aronsen, J.M., Lunde, I.G., Sjaastad, I., Carlson, C.R. and Christensen, G., 2014. Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding. PloS one, 9(3), p.e89621.

Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis.

Source: Sanden, C., Mori, M., Jogdand, P., Jönsson, J., Krishnan, R., Wang, X. and Erjefält, J.S., 2017. Broad Th2 neutralization and anti‐inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis. Immunity, Inflammation and Disease. doi:10.1002/iid3.164