PEER-REVIEWED PUBLICATIONS

Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulfate Sodium (PPS) and implications for pain associated with knee osteoarthritis.

Source: Stapledon CJM, Tsangari H, Solomon LB, Campbell DG, Hurtado P, Krishnan R, et al. (2019) Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulfate Sodium (PPS) and implications for pain associated with knee osteoarthritis. PLoS ONE 14(9): e0222602. https://doi.org/10.1371/journal.pone.0222602

Improved clinical outcome measures of knee pain and function with concurrent resolution of subchondral Bone Marrow Edema Lesion and joint effusion in an osteoarthritic patient following Pentosan Polysulfate Sodium treatment: a case report.

Source: Sampson, M., Kabbani, M., Krishnan, R., Nganga, M., Theodoulou, A., & Krishnan, J., 2017. Improved clinical outcome measures of knee pain and function with concurrent resolution of subchondral Bone Marrow Edema Lesion and joint effusion in an osteoarthritic patient following Pentosan Polysulfate Sodium treatment: a case report. BMC Musculoskeletal Disorders, 18, pp. 396-340. DOI 10.1186/s12891-017-1754-3

Pentosan Polysulfate: a Novel Glycosaminoglycan-Like Molecule for Effective Treatment of Alphavirus-Induced Cartilage Destruction and Inflammatory Disease.

Source: Herrero, L.J., Foo, S.S., Sheng, K.C., Chen, W., Forwood, M.R., Bucala, R. and Mahalingam, S., 2015. Pentosan polysulfate: A novel glycosaminoglycan-like molecule for effective treatment of alphavirus-induced cartilage destruction and inflammatory disease. Journal of virology, 89(15), pp.8063-8076.

Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function I n V i v o in Rats Subjected to Pressure Overload by Aortic Banding

Source: Vistnes, M., Aronsen, J.M., Lunde, I.G., Sjaastad, I., Carlson, C.R. and Christensen, G., 2014. Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding. PloS one, 9(3), p.e89621.

Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis.

Source: Sanden, C., Mori, M., Jogdand, P., Jönsson, J., Krishnan, R., Wang, X. and Erjefält, J.S., 2017. Broad Th2 neutralization and anti‐inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis. Immunity, Inflammation and Disease. doi:10.1002/iid3.164