Announcement PDF Appendix 3Y Change of Director’s Interest Notice Appendix 3Y Rule 3.19A.2 Change of Director’s Interest Notice Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public. Introduced 30/09/01 Amended 01/01/11 Name of entity Paradigm Biopharmaceuticals Limited ABN 94 169 346 963 We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act. Name of Director Paul Rennie Date of last notice 17 May 2023 Part 1 - Change of director’s relevant interests in securities In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part. Direct or indirect interest Direct and indirect interest Nature of indirect interest (including registered holder) Mr Paul Rennie is the legal and beneficial owner of 100% of the securities in KZEE Pty Ltd. Note: Provide details of the circumstances giving rise to the relevant interest. Mr Paul Rennie is the legal and beneficial owner of 100% of the securities in EAR Investments Pty Ltd. Date of change + See chapter 19 for defined terms. 01/01/2011 Appendix 3Y Page 1 30 November 2023 Appendix 3Y Change of Director’s Interest Notice No. of securities held prior to change Paul Rennie – 8,500,548 Fully Paid Ordinary Shares KZEE Pty Ltd ATF KZEE Superannuation Fund – 10,914,902 Fully Paid Ordinary Shares registered in the name of KZEE Pty Ltd. Mr Paul Rennie is the legal and beneficial owner of 100% of the securities in KZEE Pty Ltd. EAR Investments Pty Ltd ATF EAR Investments Trust – 1,097,355 Fully Paid Ordinary Shares registered in the name of EAR Investments Pty Ltd. Mr Paul Rennie is the legal and beneficial owner of 100% of the securities in EAR Investments Pty Ltd. Total No. of shares held after change – 20,512,805 Fully Paid Ordinary Shares Class Ordinary Shares Options Number acquired KZEE Pty Ltd ATF KZEE Superannuation Fund – 466,000 Fully Paid Ordinary Shares – 349,500 Options Expiring 30-Nov-2024 Number disposed EAR Investments Pty Ltd ATF EAR Investments Trust – 300,000 Fully Paid Ordinary Shares Value/Consideration KZEE Pty Ltd ATF KZEE Superannuation Fund – $200,380 for Fully Paid Ordinary Shares – Nil for Options Expiring 30-Nov-2024 Note: If consideration is non-cash, provide details and estimated valuation EAR Investments Pty Ltd ATF EAR Investments Trust – Nil + See chapter 19 for defined terms. Appendix 3Y Page 2 01/01/2011 Appendix 3Y Change of Director’s Interest Notice No. of securities held after change Paul Rennie – 8,500,548 Fully Paid Ordinary Shares KZEE Pty Ltd ATF KZEE Superannuation Fund – 11,380,902 Fully Paid Ordinary Shares –349,500 Options Expiring 30-Nov-2024 registered in the name of KZEE Pty Ltd. Mr Paul Rennie is the legal and beneficial owner of 100% of the securities in KZEE Pty Ltd. EAR Investments Pty Ltd ATF EAR Investments Trust – 797,355 Fully Paid Ordinary Shares registered in the name of EAR Investments Pty Ltd. Mr Paul Rennie is the legal and beneficial owner of 100% of the securities in EAR Investments Pty Ltd. Total No. of shares held after change – 20,678,805 Fully Paid Ordinary Shares Total No. of options held after change – 349,500 Options Expiring 30-Nov-2024 Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back KZEE Pty Ltd ATF KZEE Superannuation Fund – Retail entitlement offer EAR Investments Pty Ltd ATF EAR Investments Trust –Employee shares buy-back Part 2 – Change of director’s interests in contracts Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part. Detail of contract Not applicable Nature of interest Not applicable Name of registered holder (if issued securities) Not applicable + See chapter 19 for defined terms. 01/01/2011 Appendix 3Y Page 3 Appendix 3Y Change of Director’s Interest Notice Date of change Not applicable No. and class of securities to which interest Not applicable related prior to change Note: Details are only required for a contract in relation to which the interest has changed Interest acquired Not applicable Interest disposed Not applicable Value/Consideration Not applicable Interest after change Not applicable Note: If consideration is non-cash, provide details and an estimated valuation Part 3 – +Closed period Were the interests in the securities or contracts detailed No above traded during a +closed period where prior written clearance was required? If so, was prior written clearance provided to allow the trade Not applicable to proceed during this period? If prior written clearance was provided, on what date was this Not applicable provided? + See chapter 19 for defined terms. Appendix 3Y Page 4 01/01/2011