Announcement PDF 604 page 1/2 15July 2001 Form604 CorporationsAct 2001 Section 671B Notice of change of interests of substantial holder Paradigm Biopharmaceuticals Limited To Company Name/Scheme 169 346 963 ACN/ARSN 1. Details of substantial holder(1) Paul Rennie Name ACN/ARSN (if applicable) There was a change in the interests of the substantial holder on 30/11/2023 The previous notice was given to the company on The previous notice was dated 14/09/2022 14/09/2022 2. Previous and present voting power The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate(2)had a relevant interest (3) in when last required, and when now required, to give a substantial holding notice to the company or scheme, are as follows: Class of securities(4) Previous notice Person's votes Ordinary 20,391,234 Present notice Voting power (5) Person's votes 7.15% 20,678,805 Voting power (5) 5.88% 3. Changes in relevant interests Particulars of each change in, or change in the nature of, are relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows: Date of change Person whose relevant interest changed Nature of change(6) Consideration Given in relation to change(7) Class and number of securities affected Person's votes affected 20/12/2022 Paul Rennie 12/05/2023 Paul Rennie On-market trade On-market trade $61,521 $76,001 Ordinary Ordinary 47,720 73,851 30/11/2023 Kzee Pty Ltd 30/11/2023 EAR Investments Pty Ltd Retail entitlement offer Employee shares buyback $200,380 Nil Ordinary Ordinary 466,000 -300,000 4. Present relevant interests Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows: Holder of relevant interest Registered holder of securities Person entitled to be registered as holder(8) Paul Rennie Paul Rennie Paul Rennie Kzee Pty Ltd Kzee Pty Ltd EAR Investments Pty Ltd EAR Investments Pty Ltd Nature of relevant interest (6) Class and number of securities Person's votes Registered holder Ord 8,500,548 8,500,548 Paul Rennie Registered holder Ord 11,380,902 11,380,902 Paul Rennie Registered holder Ord 797,355 797,355 5. Changes in association The persons who have become associates(2)of, ceased to be associates of, or have changed the nature of their association(9) with, the substantial holder in relation to voting interests in the company or scheme are as follows: Name and ACN/ARSN (if applicable) N/A Nature of association 6. Addresses The addresses of persons named in this form are as follows: Name Paul Rennie Address 158 Seaview Road, Henley Beach South, SA 5022 Signature print name Paul Rennie sign here Capacity date Director 06/12/2023 DIRECTIONS 1. If there are a number of substantial holders with similar or related relevant interests (eg. A corporation and its related corporations, or the manager and trustee of an equity trust), the names could be included in an annexure to the form. If the relevant interests of a group of persons are essentially similar, they may be referred to throughout the form as a specifically named group if the membership of each group, with the names and addresses of members is clearly set out inparagraph6of the form. See the definition of "associate" in section 9 of the Corporations Act 2001 2. See the definition of "relevant interest" in sections608and671B(7)of the Corporations Act2001. 3. The voting shares of a company constitute one class unless divided into separate classes. 4. The person's votes divided by the total votes in the body corporate or schememultipliedby100. 5. Include details of: a. Any relevant agreement or other circumstances because of which the change in relevant interest occurred. If subsection671B (4)applies, a copy of any document setting out the terms of any relevant agreement,and a statement by the person giving full and accurate details of any contract, schemeor arrangement, must accompany this form, together with a written statement certifying this contract, scheme or arrangement;and b. Any qualification of the power of a person to exercise, control the exercise of, or influence the exercise of, the voting powers or disposal of the securities to which the relevant interest relates(indicating clearly the particular securities to which the qualification applies). c. See the definition of "relevant agreement" in section9 of the Corporations Act 2001. 6. Details of the consideration must include any and all benefits, money and other, that any person from whom a relevant interest was acquired has, or may, become entitled to receive in relation to that acquisition. Details must be included even if the benefit is conditional on the happening or not of a contingency. Details must be included of any benefit paid on behalf of the substantial holder or its associate in relation to the acquisitions, even if they are not paid directly to the person from whom the relevant interest was acquired. 7. If the substantial holder is unable to determine the identity of the person (eg. if the relevant interest arises because of an option)write "unknown". 8. Give details, if appropriate, of the present association and any change in that association since the last substantial holding notice.