Announcement PDF Appendix 3B - Proposed issue of securities Appendix 3B - Proposed issue of securities 1 / 9 Update Summary Entity name PARADIGM BIOPHARMACEUTICALS LIMITED.. Announcement Type Update to previous announcement Date of this announcement 1/6/2026 Reason for update to a previous announcement To update the correct number of shares at the completion of Share Purchase Plan, no scale back on oversubscriptions and the Number of securities that will be issued if the option is exercised to be - One fully paid ordinary share (ASX: PAR) on Page 8. Refer to next page for full details of the announcement Appendix 3B - Proposed issue of securities Appendix 3B - Proposed issue of securities 2 / 9 Part 1 - Entity and announcement details 1.1 Name of +Entity PARADIGM BIOPHARMACEUTICALS LIMITED.. We (the entity named above) give ASX the following information about a proposed issue of +securities and, if ASX agrees to +quote any of the +securities (including any rights) on a +deferred settlement basis, we agree to the matters set out in Appendix 3B of the ASX Listing Rules. If the +securities are being offered under a +disclosure document or +PDS and are intended to be quoted on ASX, we also apply for quotation of all of the +securities that may be issued under the +disclosure document or +PDS on the terms set out in Appendix 2A of the ASX Listing Rules (on the understanding that once the final number of +securities issued under the +disclosure document or +PDS is known, in accordance with Listing Rule 3.10.3C, we will complete and lodge with ASX an Appendix 2A online form notifying ASX of their issue and applying for their quotation). 1.2 Registered Number Type ACN Registration Number 169346963 1.3 ASX issuer code PAR 1.4 The announcement is 1.4a Reason for update to a previous announcement To update the correct number of shares at the completion of Share Purchase Plan, no scale back on oversubscriptions and the Number of securities that will be issued if the option is exercised to be - One fully paid ordinary share (ASX: PAR) on Page 8. 1.4b Date of previous announcement to this update 27/4/2026 1.5 Date of this announcement 1/6/2026 1.6 The Proposed issue is: An offer of +securities under a +securities purchase plan Update/amendment to previous announcement Appendix 3B - Proposed issue of securities Appendix 3B - Proposed issue of securities 3 / 9 Part 4 - Details of proposed offer under securities purchase plan Part 4A - Conditions 4A.1 Do any external approvals need to be obtained or other conditions satisfied before the offer of +securities under the +securities purchase plan issue can proceed on an unconditional basis? 4A.1a Conditions Approval/Condition +Security holder approval Date for determination 5/6/2026 Is the date estimated or actual? ** Approval received/condition met? Comments The SPP and new options will be subject to shareholder approval at an extraordinary general meeting of the Company expected to be held in early June 2025 (EGM). Estimated Yes Appendix 3B - Proposed issue of securities Appendix 3B - Proposed issue of securities 4 / 9 Part 4B - Offer details +Class or classes of +securities that will participate in the proposed issue and +class or classes of +securities proposed to be issued ASX +security code and description PAR : ORDINARY FULLY PAID Will the proposed issue of this +security include an offer of attaching +securities? Details of +securities proposed to be issued ASX +security code and description PAR : ORDINARY FULLY PAID Maximum total number of those +securities that could be issued if all offers under the +securities purchase plan are accepted 43,384,890 Reason for the update of 'Maximum total number of those +securities that could be issued if all offers under the +securities purchase plan are accepted' Will the offer be conditional on applications for a minimum number of +securities being received or a minimum amount being raised (i.e. a minimum subscription condition)? Will the offer be conditional on applications for a maximum number of +securities being received or a maximum amount being raised (i.e. a maximum subscription condition)? Will individual security holders be required to accept the offer for a minimum number or value of +securities (i.e. a minimum acceptance condition)? Is the minimum acceptance unit based or dollar based? Please enter the minimum acceptance value $ 1,000 Will individual security holders be limited to accepting the offer for a maximum number or value of +securities (i.e. a maximum acceptance condition)? Is the maximum acceptance unit based or dollar based? Please enter the maximum acceptance value $ 30,000 Dollar based ($) Yes Dollar based ($) Yes No No Yes Dollar based ($) Yes Dollar based ($) Yes No No Yes Dollar based ($) Yes Dollar based ($) Yes No No Yes Appendix 3B - Proposed issue of securities Appendix 3B - Proposed issue of securities 5 / 9 Describe all the applicable parcels available for this offer in number of securities or dollar value $1,000, $2500, $5000, $10000, $15000, $20000, $25000, $30000 Offer price details Has the offer price been determined? In what currency will the offer be made? AUD - Australian Dollar What is the offer price per +security? AUD 0.17000 Oversubscription & Scale back details Will a scale back be applied if the offer is over-subscribed? Describe the scale back arrangements If there is overwhelming subscriptions, the subscriptions may be scaled back at the company's discretion. Will these +securities rank equally in all respects from their issue date with the existing issued +securities in that class? Attaching +Security The proposed attaching security can only be of an 'Existing class' (additional +securities in a class that is already quoted or recorded by ASX) Attaching +Security - New class (+securities in a class that is not yet quoted or recorded by ASX) Details of attaching +securities proposed to be issued ISIN Code (if Issuer is a foreign company and +securities do not have +CDIs issued over them) Have you received confirmation from ASX that the terms of the proposed +securities are appropriate and equitable under listing rule 6.1? Will the entity be seeking quotation of the 'new' class of +securities on ASX? ASX +security code New class-code to be confirmed +Security description Quoted Options expiring 1 December 2026 or 20 BD post IA announcement EX $0.2375 +Security type Options Offer ratio (ratio of attaching securities at which the new +securities will be issued) The quantity of attaching +securities to be issued 1 For a given quantity of the new +securities issued 1 What will be done with fractional entitlements? Fractions rounded up to the next whole number Maximum total number of those +securities that could be issued if all offers under the +securities purchase plan are accepted Yes No New class Yes Yes Yes Yes No New class Yes Yes Yes Yes No New class Yes Yes Yes Appendix 3B - Proposed issue of securities Appendix 3B - Proposed issue of securities 6 / 9 are accepted 43,384,890 Reason for the update of 'Maximum Number of +securities proposed to be issued' SPP significantly oversubscribed above the original $2.0 million target. Offer price details Has the offer price been determined? In what currency will the offer be made? AUD - Australian Dollar What is the offer price per +security? AUD 0.23750 Please confirm whether the offer of the attaching +securities is a separate offer to the offer pursuant to the +security purchase plan Please confirm whether the attaching +securities are being offered under a +disclosure document or +PDS Oversubscription & Scale back details Will a scale back be applied if the offer is over-subscribed? Describe the scale back arrangements If there is overwhelming subscriptions, the subscriptions may be scaled back at the company's discretion. Will all the +securities issued in this class rank equally in all respects from their issue date? Options details +Security currency AUD - Australian Dollar Exercise price AUD 0.2375 Expiry date 1/12/2026 Details of the type of +security that will be issued if the option is exercised Other Description If an option is exercised, the following securities will be issued: (a) one fully paid ordinary share (ASX:PAR); and (b) one Piggyback option with an exercise price of $0.38 and expiry date of 30 April 2029 (see details of these ataching securities below) Please provide a URL link for a document lodged with ASX setting out the material terms of the +securities proposed to be issued or provide the information by separate announcement. Please refer to the announcement lodged today. Details of attaching +securities proposed to be issued ISIN Code (if Issuer is a foreign company and +securities do not have +CDIs issued over them) Have you received confirmation from ASX that the terms of the proposed +securities are appropriate and Will the entity be seeking quotation of the 'new' class of +securities on ASX? Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Appendix 3B - Proposed issue of securities Appendix 3B - Proposed issue of securities 7 / 9 of the proposed +securities are appropriate and equitable under listing rule 6.1? +securities on ASX? ASX +security code New class-code to be confirmed +Security description Quoted Options expiring 30 April 2029 EX $0.38 +Security type Options Offer ratio (ratio of attaching securities at which the new +securities will be issued) The quantity of attaching +securities to be issued 1 For a given quantity of the new +securities issued 1 What will be done with fractional entitlements? Fractions rounded up to the next whole number Maximum total number of those +securities that could be issued if all offers under the +securities purchase plan are accepted 43,384,890 Reason for the update of 'Maximum Number of +securities proposed to be issued' Offer price details Has the offer price been determined? In what currency will the offer be made? AUD - Australian Dollar What is the offer price per +security? AUD 0.38000 Please confirm whether the offer of the attaching +securities is a separate offer to the offer pursuant to the +security purchase plan Please confirm whether the attaching +securities are being offered under a +disclosure document or +PDS Oversubscription & Scale back details Will a scale back be applied if the offer is over-subscribed? Describe the scale back arrangements If there is overwhelming subscriptions, the subscriptions may be scaled back at the company's discretion. Will all the +securities issued in this class rank equally in all respects from their issue date? Options details +Security currency AUD - Australian Dollar Exercise price AUD 0.3800 Expiry date 30/4/2029 Details of the type of +security that will be issued if the option is exercised PAR : ORDINARY FULLY PAID Number of securities that will be issued if the option is exercised Yes Yes Yes Yes Yes Yes No Yes Yes Yes Yes Yes Yes No Yes Yes Yes Yes Yes Yes No Appendix 3B - Proposed issue of securities Appendix 3B - Proposed issue of securities 8 / 9 Number of securities that will be issued if the option is exercised 10,526,316 Please provide a URL link for a document lodged with ASX setting out the material terms of the +securities proposed to be issued or provide the information by separate announcement. Please refer to the announcement lodged today. Part 4C - Timetable 4C.1 Date of announcement of +security purchase plan 27/4/2026 4C.2 +Record date 24/4/2026 4C.3 Date on which offer documents will be made available to investors 30/4/2026 4C.4 Offer open date 4/5/2026 4C.5 Offer closing date 26/5/2026 4C.7 +Issue date and last day for entity to announce results of +security purchase plan offer 2/6/2026 Part 4D - Listing Rule requirements 4D.1 Does the offer under the +securities purchase plan meet all of the requirements of listing rule 7.2 exception 5 or do you have a waiver from those requirements? 4D.1a Are any of the +securities proposed to be issued without +security holder approval using the entity's 15% placement capacity under listing rule 7.1? 4D.1b Are any of the +securities proposed to be issued without +security holder approval using the entity's additional 10% placement capacity under listing rule 7.1A (if applicable)? Part 4E - Fees and expenses 4E.1 Will there be a lead manager or broker to the proposed offer? 4E.2 Is the proposed offer to be underwritten? No No No No Appendix 3B - Proposed issue of securities Appendix 3B - Proposed issue of securities 9 / 9 4E.3 Will brokers who lodge acceptances or renunciations on behalf of eligible +security holders be paid a handling fee or commission? 4E.4 Details of any other material fees or costs to be incurred by the entity in connection with the proposed offer Part 4F - Further Information 4F.01 The purpose(s) for which the entity intends to use the cash raised by the proposed issue To support the costs of the PARA_OA_012 Phase 3 clinical trial through key data readouts, including interim analysis and preparation for NDA submission package. 4F.1 Will the entity be changing its dividend/distribution policy if the proposed offer is successful? 4F.2 Countries in which the entity has +security holders who will not be eligible to accept the proposed offer Registered holders outside of Australia and New Zealand are excluded for the SPP 4F.3 URL on the entity's website where investors can download information about the proposed offer https://paradigmbiopharma.com/ 4F.4 Any other information the entity wishes to provide about the proposed offer No No No