Announcement PDF ASX RELEASE 22 October 2026 Further Obsidian Note Redemption Paradigm Biopharmaceuticals Limited (Administrators Appointed) (ASX: PAR) ("Paradigm" or "the Company") advises that, following discussions with Obsidian Global GP, LLC ("Obsidian"), the parties have agreed to the redemption and cancellation of a further 290,993 convertible notes for a cash payment of US$348,900.38 (approximately A$500,000). The notes were redeemed and cancelled upon completion of the payment. Following the redemption and cancellation, 2,834,715 convertible notes remain outstanding. The redemption is pursuant to the Convertible Securities Agreement and Share Placement Agreement dated on or about 1 July 2025 and the Deed of Variation dated on or about 29 April 2026, which Is secured by a general security agreement over the Company’s assets.. -Ends- Authorised for release by the Voluntary Administrators*. To learn more please visit: www.paradigmbiopharma.com FOR FURTHER INFORMATION PLEASE CONTACT: Media Enquiries Creditor and Supplier Enquiries Investor Shane Murphy Strategic Communications FTI Consulting T: +61 (0) 420 945 291 E: shane.murphy@fticonsulting.com James Dunne Corporate Finance FTI Consulting T: +61 8 6430 1303 E: James.Dunne@fticonsulting.com Simon White Director of Investor Relations Paradigm Biopharma E: investorrelations@paradigmbiopharma.com *Christopher Pattinson and Hayden White of FTI Consulting were appointed as joint and several voluntary administrators of Paradigm Biopharmaceuticals Limited (Administrators Appointed) ACN 169 346 963 on 29 September 2026.